Nature paper reports a cold-activated metabolic network that extends lifespan in a laboratory worm
26 October 2026
A paper published in Nature reports that cold temperature activates a BH2 metabolic network that promotes longevity and protects proteins in the nematode Caenorhabditis elegans.
Cold raises levels of the enzyme CAT-4, called GCH1 in humans, which increases production of dihydrobiopterin, or BH2.
BH2 is described as a transportable reservoir for the bioactive cofactor tetrahydrobiopterin, or BH4.
Muscle makes BH2, which travels to tissues such as the intestine and neurons, where the enzyme DHFR-1 converts it into BH4.
BH4 is a cofactor for PAH-1, which drives tyrosine synthesis and extends lifespan, and the pathway also prevents disease-related protein aggregation and neuronal dysfunction during ageing.
In human cells, supplying BH2 or tyrosine reduced the aggregation of polyQ-expanded huntingtin and of mutant TDP-43 and FUS linked to amyotrophic lateral sclerosis.
In plain words
Proteostasis Protein homeostasis — The cell's system for keeping its proteins correctly folded and functional.
ALS Amyotrophic lateral sclerosis — A progressive disease of the nerve cells that control voluntary muscle movement.